As a science with around 5000-year-old tradition, it is certainly evident that Ayurveda must have undergone developmental changes and status-based impact over the years. It is worth giving a look on how it evolved as one of the mainstream medical systems, overcoming the challenges and continues to enjoy its superficial status with all its glory. The influence of civilizations, religious beliefs and different schools of thoughts in various eras are certainly evident in the literature of ancient times. All such cultural and spiritual influences from various fields rightly contributed to the upliftment of Ayurveda during each period. The period from 5th millennium BC to 3rd century AD witnessed several changes and development in Ayurveda while undergoing tremendous influence from different communities and civilizations.